Comprende y desarrolla tus competencias en el abordaje y manejo de las complicaciones del paciente trasplantado de progenitores hematopoyéticos a corto, medio y largo plazo”

El trasplante de Progenitores Hematopoyéticos se ha usado como tratamiento en diversas enfermedades hematológicas y oncológicas, siendo reservado para aquellos pacientes que no tienen otra posibilidad de tratamiento. Esto no quiere decir, que es un proceso que esté exento de riesgo o de desarrollarse una situación que genere estrés en pacientes pediátricos. Por tanto, se debe contar con el apoyo de la familia y los profesionales para que los niños se sientan seguros en este proceso.  

De esta forma, la Postgraduate diploma en Allogeneic HSCT in Pediatrics for Nursing brindará a los estudiantes toda la información necesaria y actualizada en este campo. Se comenzará por brindarle al alumno los conocimientos y habilidades necesarios para el reconocimiento, manejo y estabilización inicial del paciente hematológico pediátrico que sufre un compromiso vital derivado de alguna complicación de su enfermedad de base, por un proceso intercurrente o por consecuencias indeseadas de su tratamiento, de manera efectiva, segura y coordinada, e integrando sus intervenciones con el resto de los servicios del sistema sanitario a nivel hospitalario.  

En los siguientes módulos, se podrá tener una visión más ampliada sobre el proceso que se realiza para identificar a los pacientes pediátricos con patología hematológica candidatos a trasplante de progenitores hematopoyéticos alogénico. De esta forma, se buscará que los estudiantes adquieran las competencias necesarias para garantizar un cuidado integral de los pacientes durante todas las etapas de este procedimiento.  

Llegando al final del programa, el profesional habrá desarrollado el conjunto de competencias de conocimiento y habilidades, para el abordaje y manejo integral del de los niños y adolescentes con patología hematológica grave y sus familias. Todo esto, tomando en cuenta el papel facilitador y emocional de los enfermeros en el campo de la hematología pediátrica.  

El equipo docente reunido para esta Postgraduate diploma es de reconocido prestigio y dispone de una amplia experiencia en unidades de referencia a nivel nacional e internacional en el tratamiento y cuidados de los recién nacidos, niños y adolescentes con enfermedad hematológica. Se cuenta con un programa 100% online que aporta al alumno la facilidad de poder cursarlo cómodamente, donde y cuando quiera. Solo necesitará un dispositivo con acceso a internet para lanzar su carrera un paso más allá. Una modalidad acorde al tiempo actual con todas las garantías para posicionar al enfermero en un sector altamente demandado. 

Comprende la importancia de la comunicación terapéutica en el cuidado de los niños y adolescentes con patología hematológica grave y sus familiares” 

Esta Postgraduate diploma en Allogeneic HSCT in Pediatrics for Nursing contiene el programa científico más completo y actualizado del mercado.Sus características más destacadas son:

• El desarrollo de casos prácticos presentados por expertos en Hematología Pediátrica para Enfermería
• Los contenidos gráficos, esquemáticos y eminentemente prácticos con los que está concebido recogen una información científica y práctica sobre aquellas disciplinas indispensables para el ejercicio profesional
• Los ejercicios prácticos donde realizar el proceso de autoevaluación para mejorar el aprendizaje
• Su especial hincapié en metodologías innovadoras
• Las lecciones teóricas, preguntas al experto, foros de discusión de temas controvertidos y trabajos de reflexión individual
• La disponibilidad de acceso a los contenidos desde cualquier dispositivo fijo o portátil con conexión a internet

Realiza un plan integral de atención al niño con enfermedad incurable y a su familia, siguiendo un programa avalado por un excelente equipo docente”

El programa incluye, en su cuadro docente, a profesionales del sector que vierten en esta capacitación la experiencia de su trabajo, además de reconocidos especialistas de sociedades de referencia y universidades de prestigio.

Su contenido multimedia, elaborado con la última tecnología educativa, permitirá al profesional un aprendizaje situado y contextual, es decir, un entorno simulado que proporcionará una capacitación inmersiva programada para entrenarse ante situaciones reales.

El diseño de este programa se centra en el Aprendizaje Basado en Problemas, mediante el cual el profesional deberá tratar de resolver las distintas situaciones de práctica profesional que se le planteen a lo largo del programa. Para ello, contará con la ayuda de un novedoso sistema de vídeo interactivo realizado por reconocidos expertos.

Comprende las situaciones más frecuentes en las que el niño y adolescente con enfermedad hematológica grave precisa de cuidados intensivos”

Alcanza los conocimientos y habilidades suficientes para poder desarrollar las actitudes personales y profesionales necesarias para acoger a los niños y adolescentes y sus familias que van a ser sometidos a un alo-TPH”

To ensure that students meet the requirements of nursing applied to pediatric patients who will receive allogeneic HSCT treatment, a syllabus has been developed whose modules offer a broad perspective of this field of action, allowing the student to achieve sufficient knowledge and skills to be able to develop the personal and professional attitudes necessary to care for children and adolescents and their families who are going to undergo allo-HPCT. From module 1, students will see their knowledge broadened, which will enable them to develop professionally, knowing that they can count on the support of a team of experts. 

Identifies the facilitating role and emotional competency profile of pediatric hematology nurses following a program supported by the experience of an excellent faculty" 

Module 1. All Together as a Team

1.1. Emergency Nursing Care in the Pediatric Patient with Hematologic Pathology

1.1.1. Definition of Urgency in the Child with Severe Hematologic Pathology
1.1.2. Most Common Emergencies in Children with Severe Hematologic Pathology

1.1.2.1. According to Etiology
1.1.2.2. According to Affected Organs

1.1.3. Most Frequent Reasons for Admission to the Emergency Department in Children with Severe Hematologic Pathology
1.1.4. Performance in the Most Common Emergencies

1.1.4.1. Hyperleukocytosis
1.1.4.2. Febrile Neutropenia
1.1.4.3. Immune Reconstitution Inflammatory Syndrome (IRS)
1.1.4.4. Cytokine Release Syndrome
1.1.4.5. Severe Pain
1.1.4.6. Acute Methotrexate Toxicity
1.1.4.7. Transfusion Reactions
1.1.4.8. Extravasations
1.1.4.9. Intrathecal Chemotherapy Side Effects

1.1.5. Management of Oxygen Therapy, Fluid Therapy, Main Drugs and Electromedicine Devices and Administration of drugs
1.1.6.    Emergency response
1.1.7. Cardiorespiratory Arrest Trolley
1.1.8. Training of the Assistance Team
1.1.9. Communication with the Family and the Child/Adolescent

1.2. Nursing Care of Pediatric Patients With Hematologic Diseases and Their Family, Admitted to the PICU(I)

1.2.1. Initial Assessment of the PICU Patient
1.2.2. Common Complications Requiring Intensive Care

1.2.2.1. Complications Related to the Underlying Disease and its Treatment

1.2.2.1.1. Respiratory Insufficiency
1.2.2.1.2. Cardiac Alterations
1.2.2.1.3. Alteration of the Hematological System
1.2.2.1.4. Acute Kidney Failure
1.2.2.1.5. Metabolic Alterations
1.2.2.1.6. Hepatic Toxicity

1.2.2.2. Complications Related to the Postoperative Period in Neurosurgery

1.2.3. Basic Nursing Care in the Pediatric Patient Admitted to the PICU
1.2.4. Nutritional Aspects of the PICU Patient
1.2.5. Special Situations in the Oncologic Patient

1.2.5.1. Patient Requiring Continuous Renal Replacement Therapy (CRRT)
1.2.5.2. Patient Subjected to High Frequency Mechanical Ventilation (HFMV)

1.3. Nursing Care of the Pediatric Patient with Hematologic Disease and Family, Admitted to the PICU (II)

1.3.1. Initial Comprehensive Care for the Family of the Hematologic Patient Admitted to the PICU
1.3.2. Psychological Aspects in Children with Hematologic Pathology Requiring Intensive Care

1.3.2.1. Pain Management
1.3.2.2. Treatment Anxiety
1.3.2.3. Fear of Death

1.3.3. Bereavement in the Oncologic Patient Admitted to the PICU
1.3.4. Special Situations of the Oncologic Patient Admitted to the PICU

1.3.4.1. Communication with the Oncology Patient Subjected to Mechanical Ventilation
1.3.4.2. Rehabilitation (Respiratory and Motor Physiotherapy)

1.3.5. Medical Information and Care Team-Family Unit Communication
1.3.6. End-of-Life Care for Oncology Patients

1.4. Pediatric Intensive Care Unit (PICU). Humanization Projects

1.4.1. General Criteria for Admission of Hematologic Patients to the PICU
1.4.2. Family Repercussions of Admission to the PICU
1.4.3. Humanistic Vision of Critical Care
1.4.4. Care Model: Family-Centered Care

1.4.4.1. Family Empowerment
1.4.4.2. Emotional Well-Being

1.4.5. Characteristics of the Care Team in a Humanistic PICU
1.4.6. Humanizing Strategies in an Open-Door PICU

1.5. Psychological Support of of the Child with Severe Hematologic Pathology

1.5.1. Developmental Stage of Childhood
1.5.2. The Child with Severe Hematologic Disease

1.5.2.1. Specific Characteristics
1.5.2.2. Psychological Care for Children and Families

1.5.2.2.1. General Aspects
1.5.2.2.2. According to the Stage of the Disease

1.5.3. Survivors of Childhood Hematologic Malignant Hematologic Disease and Quality of Life
1.5.4. Death in Childhood

1.5.4.1. Palliative Care
1.5.4.2. Grief

1.6.  Psychological Support for Adolescents During the Process of Living with a Serious Hematological Disease

1.6.1. Adolescent Developmental Stage
1.6.2. The Adolescent with Severe Hematologic Disease

1.6.2.1. Specific Characteristics of the Adolescent with Severe Hematologic Disease
1.6.2.2. Psychological Care in the Phases of the Disease

1.6.2.2.1. Diagnosis
1.6.2.2.2. Treatment
1.6.2.2.3. Post Treatment

1.6.3. Survivors in Adolescence and Quality of Life
1.6.4. Death in Adolescence

1.7. Foundations and Associations of Parents of Children with Hematologic Pathology and other NGOs

1.7.1. Spanish Federation of Parents of Children with Cancer (FEPNC)

1.7.1.1. The Federation
1.7.1.2. Member Associations
1.7.1.3. The Example of AFANOC-Association of Relatives and Friends of Children with Oncology in Catalonia

1.7.2. Spanish Association of Primary Immune Deficits
1.7.3. Barcelona PID Foundation
1.7.4. Other Associations and/or Foundations

1.7.4.1. El somni dels Nens Foundation
1.7.4.2. Enriqueta Villavecchia Foundation
1.7.4.3. Spanish Fanconi Anemia Association
1.7.4.4. Association of affected Blackfan Diamond Spain
1.7.4.5. Spanish Hemophilia Foundation

1.7.5. Volunteering in Pediatric OncoHematology Units

1.7.5.1. The Importance and Coordination of Volunteerism
1.7.5.2. Lines of Volunteer Work in Pediatric Oncology
1.7.5.3. Volunteer Training

1.7.6. Regulatory Framework for Volunteering

1.8. Educational Continuity in Children and Adolescents with Hematologic Pathology

1.8.1. Educational Care as a Right; Principles of Educational Care for Students with Illnesses
1.8.2. Requirements and Procedures
1.8.3. Academic Coverage During the Sickness Process

1.8.3.1. In-Hospital. Hospital Classrooms (AAHH)
1.8.3.2. Home-Based Educational Support Service

1.9. Information and Communication Technologies (ICTs) and Humanization

1.9.1. Use of ICT and E-health for Parents

1.9.1.1. Decalogue for the Good use of ICTs
1.9.1.2. ICTs as a Method of Distraction and Relief from Pain and Anxiety in Children and Adolescents
1.9.1.3. ICTs as a Method of Communication and Learning

1.9.2. Use of ICT and e-Health for Parents

1.9.2.1. Information Needs
1.9.2.2. Communication Needs
1.9.2.3. Development and Prescription of Apps and Websites in Pediatric Oncology
1.9.2.4. Use of Social Networks

1.9.3. Use of ICTs and e-Health in Health Professionals

1.9.3.1. New Technologies and New Challenges for the Nursing Professional
1.9.3.2. Application of New Technologies in Health Care
1.9.3.3. Useful Applications for Pediatric Hematology Nurses
1.9.3.4. ICT Applications in the Healthcare of the Future

Module 2. Towards Healing: Allogeneic HSCT in Pediatrics

2.1. Introduction and Indications for Allogeneic Hematopoietic Progenitor Transplantation

2.1.1. Hematopoietic Progenitors (HP) and PHT
2.1.2. The Histocompatibility System (HLA or MHC)
2.1.3. The History Hematopoietic Progenitor Transplantation
2.1.4. Types of Hematopoietic Progenitor Transplantation

2.1.4.1. Depending on the Donor
2.1.4.2. According to the Source of the Hematopoietic Progenitor Cells

2.1.5. Indications for Allogeneic HSCT 

2.1.5.1. Patients with Hematologic Malignancies 

2.1.5.1.1. Leukemias
2.1.5.1.2. Myelodysplastic Syndromes
2.1.5.1.3. Lymphomas

2.1.5.2. Patients with NO Malignancies 

2.1.5.2.1. Erythrocyte Alterations
2.1.5.2.2. Primary Immunodeficiencies
2.1.5.2.3. Congenital Spinal Insufficiencies
2.1.5.2.4. Others 

2.2. From Donor Selection to Infusion of Hematopoietic Progenitors  

2.2.1. Donor Selection 

2.2.1.1. Related Donors
2.2.1.2. Search for Unrelated Donors
2.2.1.3. Choice of Donor

2.2.2. PH Collection Techniques

2.2.2.1. Cord Blood Progenitor Procurement and Handling
2.2.2.2. Mobilization and Collection of Peripheral Blood Progenitor Cells
2.2.2.3. Bone Marrow Progenitor Cell Harvesting by Direct Bone Marrow Aspiration

2.2.3.Transportation of PHs (from Hospital of origin to Receiving Hospital)

2.2.3.1. Bag Labeling
2.2.3.2. Container Labeling
2.2.3.3. Documentation
2.2.3.4. Temperature

2.2.4. PH Management and Conservation 

2.2.4.1. Quality Control of Cell Processing
2.2.4.2. Handling Prior to Cryopreservation
2.2.4.3. Cryopreservation
2.2.4.4. Defrosting
2.2.4.5. Transport to the Hospital TPH Unit for Infusions

2.3. Nursing During the Conditioning of the Child/Adolescent Undergoing Allo-PHPT 

2.3.1. Patient and Family Welcome
2.3.2. Patient Assessment
2.3.3. Conditioning Regimes

2.3.3.1. Total Body Irradiance (TBI)
2.3.3.2. Chemotherapy

2.3.4. Prophylaxis of Graft-Versus-Host Disease (GVHD)

2.3.4.1. Methotrexate
2.3.4.2. Infliximab and Rituximab
2.3.4.3. Cyclosporine
2.3.4.4. Mycophenolate
2.3.4.5. ATG
2.3.4.6. Cyclophosphamide
2.3.4.7. Corticoids
2.3.4.8. Nonspecific Immunoglobulins 

2.3.5. PProphylaxis of Sinusoidal Obstructive Syndrome (SOS) 
2.3.6. Infection Prophylaxis

2.3.6.1. Protected Environment Settings
2.3.6.2. Low Bacterial Diet
2.3.6.3. Pharmacological Prophylaxis 

2.3.7. Patient and Family Accompaniment 

2.4. Day 0. Infusion of Hematopoietic Progenitors 

2.4.1. Day 0
2.4.2. Patient Preparation
2.4.3. Parent's Reception
2.4.4. Progenitor Infusion
2.4.5. Potential Complications
2.4.6. Post Infusion Care of Progenitors

2.4.6.1. Patient Care
2.4.6.2. Family Care

2.5. Phase of Medullary Aplasia. Nursing care

2.5.1.    Duration of the Spinal Cord Aplasia Phase
2.5.2.    Potential Complications of the Spinal Cord Aplasia Phase
   

2.5.2.1. Directly Derived from the Conditioning Treatment
2.5.2.2. Produced by the Situation of Aplasia

2.5.2.2.1. Infections
2.5.2.2.2. Nausea and Vomiting
2.5.2.2.3. Diarrhea
2.5.2.2.4. Mucositis
2.5.2.2.5. Hemorrhages
2.5.2.2.6. Respiratory Problems

2.5.3.    Nursing Assessment and Interventions

2.6. Mid-Term Nursing Care of the Transplanted Child/Adolescent and his or her Family 

2.6.1. Duration of the Post-Transplant Phase in the Medium Term
2.6.2. Potential Complications of the Post-Transplant Phase in the Medium Term

2.6.2.1. Infections
2.6.2.2. Graft-Versus-Host Disease
2.6.2.3. Implant and Pre-Implant Syndrome
2.6.2.4. Implant/Graft Failure
2.6.2.5. Other complications 

2.6.2.5.1. Hemorrhagic Cystitis
2.6.2.5.2. Renal Dysfunction
2.6.2.5.3. Thrombotic Microangiopathy
2.6.2.5.4. Idiopathic Pneumonia Syndrome (IPS)
2.6.2.5.5. Diffuse Alveolar Hemorrhage 

2.6.3. Nursing Assessment and Interventions

2.7. Most Relevant Emergencies in Post-Transplant Patients  

2.7.1. Introduction
2.7.2. Sepsis and Septic Shock
2.7.3. Mucositis Grade III-IV
2.7.4. Implant Syndrome
2.7.5. Capillary Hyperpermeability Syndrome (CLS)
2.7.6. Acute GVHD and Chronic GVHD
2.7.7. Hemorrhagic Cystitis
2.7.8. Sinusoidal Obstructive Syndrome of the Liver (SOS)
2.7.9. Posterior Reversible Encephalopathy Syndrome (PRES)
2.7.10. Acute Kidney Failure
2.7.11. Respiratory Failure Post-HPT

2.7.11.1. Idiopathic Pneumonia Syndrome (IPS)
2.7.11.2. Diffuse Alveolar Hemorrhage (HAD)
2.7.11.3. Organizational Cryptogenic Pneumonia (COP)
2.7.11.4. Bronchiolitis Obliterans Syndrome (BOS)

2.7.12. Post-TPH Thrombotic Microangiopathy (MAT)
2.7.13. Cardiac Toxicity
2.7.14. Multiorgan Dysfunction Syndrome (SDMO)
2.7.15. Transfer the Intensive Care Unit 

2.8. Follow-Up HPT Nursing Consultation 

2.8.1. La TPH nursing consultation
2.8.2. Nursing Care in the Pre-Hematopoietic Progenitor Transplant Consultation 

2.8.2.1. Information About the Process
2.8.2.2. Welcome to the TPH Unit and Basic Recommendations for Operation
2.8.2.3. Anthropometric Measurements and Vital Signs
2.8.2.4. Peripheral Blood Analysis Pre-TPH
2.8.2.5. Presentation of the Multidisciplinary Team
2.8.2.6. Emotional Support to the Patient and Family
2.8.2.7. Resolution of Doubts

2.8.3. Nursing Care in Post-HPCT Follow-up Consultations 

2.8.3.1. Short-Term 

2.8.3.1.1. Review of Information Provided at Discharge from Hospitalization
        2.8.3.1.2. Surveillance Signs and Symptoms, Information on Warning Signs, Early Detection of Complications
        2.8.3.1.3. Information on Measures to Avoid Infection: Avoid Contact with People with Flu-like Symptoms, Avoid Crowded Indoor Spaces
        2.8.3.1.4. Dietary and Nutritional Recommendations
        2.8.3.1.5. Vascular Access Care and Monitoring: PAC, PICC
        2.8.3.1.6. Care and Monitoring of Nutritional Support Devices: SNG, Gastric Button
        2.8.3.1.7. Pain Assessment
        2.8.3.1.8. Activity Evaluation
        2.8.3.1.9. Health Education
        2.8.3.1.10. Information About Day Hospital Circuits
        2.8.3.1.11. Emotional Support to the Patient and Family

2.8.3.2. In the long term 

2.8.3.2.1. Monitoring Signs and Symptoms
2.8.3.2.2. Early Detection of Toxicity Complications
2.8.3.2.3. Coordination with other Specialists: Cardiology, Endocrinology and Traumatology
2.8.3.2.4. Chronic Follow-Up: Symptomatic Treatments, Emotional Support, Adherence to Treatment
2.8.3.2.5. Follow-Up Immunizations Post-TPH
2.8.3.2.6. Health Education on Healthy Habits for Children and Adolescents

2.9. New Therapies in the Treatment of Post allo-HPT Complications

2.9.1. Donor CD34+ Progenitor Infusion for the Treatment of Implant Failure Secondary to Allogeneic HPT 

2.9.1.1. Candidate Patients
2.2.1.2. Procedure

2.9.2. Extracorporeal Photopheresis for the Treatment of GVHD 

2.2.2.1. Candidate Patients
2.2.2.2. Procedure

2.9.3. Mesenchymal Stem Cell Infusion for the Treatment of GVHD

2.9.3.1. Candidate Patients
2.2.3.2. Procedure

2.9.4. Donor Lymphocyte Infusion. Immunotherapy in Patients Relapsing after allogeneic HSCT 

2.9.4.1. Candidate Patients
2.9.4.2. Procedure

Module 3. When the response to treatment is not adequate 

3.1. Introduction

3.1.1. Response to Disease
3.1.2. Definition of Survival
3.1.3. Definition of Recurrence
3.1.4. Diseases or Situations with Higher Likelihood of Recurrences
3.1.5. Treatment Options
3.1.6. Welcoming and Accompanying in the Recurrence of the Disease

3.1.6.1. Parents 

3.1.6.1.1. Emotional Reactions
3.1.6.1.2. Facing

3.1.6.2. Emotional Reactions and Coping with Relapse in Children and Adolescents  

3.2. Concept, Rationale and Need for Clinical Trials in Pediatric Hematology 

3.2.1. What is a Clinical Trial?
3.2.2. Historical Background, Legislation and Ethics of Experimentation with Drugs

3.2.2.1. "The Canon of Medicine" Avicenna (Ibn Sina)
3.2.2.2. First Clinical Trial in History. James Lind
3.2.2.3. Experiments on Children in the Auschwitz Concentration Camp (Josef Mengele)
3.2.2.4. Nuremberg Code (1946)
3.2.2.5. Ethically Questionable Clinical Trials after the Nuremberg Code
3.2.2.6. Declaration of Helsinki (1964)
3.2.2.7. Good Clinical Practice Guidelines (1995)

3.2.3. Why are CCS Necessary in Pediatric Hematology? 

3.2.3.1. Increase Overall Survival of Patients with Poor Prognosis
3.2.3.2. Decrease Long-Term Sequelae

3.3. Design, Preparation and Implementation of a Clinical Trial 

3.3.1. Design of a Clinical Trial
3.3.2. Phases of Clinical Trials
3.3.3. Identification and Selection of Participating Centers
3.3.4. Role of the Competent Authorities: CEIm and AEMPSCE
3.3.5. Medication and Hospital Pharmacy Service
3.3.6. Sample Analysis Laboratories
3.3.7. Economic Aspects of the Clinical Trial
3.3.8. Archive

3.4. Development of an Open Clinical Trial in a Center and Professionals Involved 

3.4.1. Initiation Visit
3.4.2. Monitoring Visit
3.4.3. Closing Visit
3.4.4. Investigators File
3.4.5. Management of Adverse Events
3.4.6. Trial Medication
3.4.7. Inclusion of Patients
3.4.8. Trial Drug Administration, Disease Evaluation and Follow-Up
3.4.9. Professionals Involved in a Clinical Trial

3.4.9.1. Professionals in the Hospital Field
3.4.9.2. Pharmaceutical Company Professionals

3.5. Role of the Nursing Professional in EECC in Pediatric Hematology

3.5.1. Nurse in the Clinical Trials team in Pediatric OncoHematology
3.5.2. Specific Training Requirements 

3.5.2.1. Training in Good Clinical Practices
3.5.2.2. Training in Handling and Shipping of Biohazard Samples
3.5.2.3. Training Specific to Each Clinical Trial

3.5.3. Responsibilities
3.5.4. Delegated Clinical Trial Activities 

3.5.4.1. Material Management

3.5.4.1.1. Fungibles
3.5.4.1.2. Non-Expendable 

3.5.4.2. Management of Local Laboratory Samples
3.5.4.3. Central Laboratory Sample Management
3.5.4.4. Nursing Techniques
3.5.4.5. Drug Administration
3.5.4.6. Source Records
3.5.4.7. Electronic Data Collection Notebook 

3.5.5. Nursing care

3.5.5.1. Basic Needs Care
3.5.5.2. Accompaniment

3.6. Current status and Future of Pediatric Hematology. Personalized Medicine

3.6.1. Science and Economics
3.6.2. Fundamentals of Translational Research
3.6.3. Definition Personalized Medicine
3.6.4. High-Throughput Sequencing Techniques
3.6.5. Data Analysis
3.6.6. Bio markers
3.6.7. Preclinical Models

3.7. Introduction, Objectives and Stages of the Therapeutic Approach in Pediatric PCPCs

3.7.1. History of Palliative Care
3.7.2. Difficulties in the Application of the CCPPs in the Pediatric Population. The Challenge of Pediatric Palliative Care
3.7.3. Definition of Pediatric Palliative Care
3.7.4. Pediatric Palliative Care Care Groups
3.7.5. Peculiarities of Pediatric Palliative Care
3.7.6. Universal Principles of the CCPP
3.7.7. Objectives of the Palliative Approach
3.7.8. Advanced Disease Situation. Turning Point
3.7.9. Stages of the Therapeutic Approach
3.7.10. Place of Care: Hospital vs. Domiciliary

3.8. Symptom Management in Pediatric Hematology (including pain) in CCPP

3.8.1. Diagnosis and Evaluation of the Symptoms
3.8.2. General Principles of Symptom
3.8.3. Symptoms to Alleviate 

3.8.3.1. Main Symptom to Alleviate: Pain
3.8.3.2. General Symptoms
3.8.3.3. Constitutional Symptoms
3.8.3.4. Respiratory Symptoms
3.8.3.5. Digestive Symptoms
3.8.3.6. Neurological Symptoms
3.8.3.7. Other Symptoms 

3.8.4. Prevention and Treatment 

3.8.4.1. Non-pharmacological methods
3.8.4.2. Pharmacological Measures

3.9. Total Pain and Ethical Issues in Pediatric PPACs

3.9.1. Total Pain

3.9.1.1. Cicely Saunders 
3.9.1.2. Concept of Total Pain
3.9.1.3. Pain Threshold
3.9.1.4. Basic Principles of Total Pain Relief
3.9.1.5. Pain, Suffering and Death
3.9.1.6. Barriers in the Management of Total Pain in Pediatric OncoHematology
3.9.1.7. Dying with Dignity

3.9.2. Ethical Aspects 

3.9.2.1. Definition of Ethics and Bioethics
3.9.2.2. Basic Principles of Bioethics
3.9.2.3. Ethical Issues and Legal Rights of Children undergoing Pediatric Palliative Care
3.9.2.4. Legislation Applied to Minors
3.9.2.5. Communication and Decision Making
3.9.2.6. Deliberation in Decision Making
3.9.2.7. Health Care Ethics Committees

3.10. Nursing Care During the Terminal Phase and Last-Day Situation in Pediatric PCPCs 

3.10.1. Diagnostic Principles of the Terminal Phase
3.10.2. Agony Phase or Last Days Situation (LDS) 

3.10.2.1. Concept
3.10.2.2. Signs and Symptoms of the Dying Phase
3.10.2.3. Therapeutic Objectives
3.10.2.4. Symptom Control
3.10.2.5. Family Care
3.10.2.6. Palliative Sedation
3.10.2.7. Adjustment of Pharmacological Treatment

3.10.3. Palliative Sedation

Module 4. Welcoming, Caring and Accompanying in Pediatric Hematology

4.1. Comprehensive View of the Care of the Child with Hematologic Pathology and their Family

4.1.1. A Comprehensive Look at Human Health 

4.1.1.1. Physical Health
4.1.1.2. Mental Health
4.1.1.3. Emotional Health
4.1.1.4. Social Health
4.1.1.5. Spiritual Health

4.1.2. The Nurse’s Eye

4.1.2.1. Emotions, Beliefs and Professional Development
4.1.2.2. Welcoming, Caring and Accompanying
4.1.2.3. Biomedical Model
4.1.2.4. Salutogenic Model

4.1.3. Systemic Approach to Care

4.1.3.1. Consistency of the Person
4.1.3.2. System Consistency
4.1.3.3. Consistency of the “Soul”

4.1.4. Welcoming, Caring for and Accompanying in a Comprehensive Manner

4.1.4.1. Nursing Roles and Competencies
4.1.4.2. The Interdisciplinary Work of Professionals
4.1.4.3. Transdisciplinary Challenges for the Nurse Practitioner

4.2. Theories and Models That Approach the Integral Vision of Nursing

4.2.1. The Salutogenic Model Applied to Care

4.2.1.1. Welfare Assets
4.2.1.2. Development of Personal Assets
4.2.1.3. Development of System Assets
4.2.1.4. Development of Institutional Assets

4.2.2. Development of Personal Assets
4.2.3. Helping Relationship Model: Hildegarde Peplau
4.2.4. Health Promotion Model: Nola Pender
4.2.5. Diversity Theory and Universality of Care: Madeleine Leininger
4.2.6. Human Care Theory: Jean Watson
4.2.7. Comfort Theory: Katharine Kolkaba
4.2.8. Marie Françoise Colliére. Promoting Life

4.3. The Facilitating Role of Nursing in Pediatric Hematology

4.3.1. The role of the Facilitator
4.3.2. The Nursing Perspective
4.3.3. Facilitating Care from the Different Nursing Roles
4.3.4. Humanization of Care
4.3.5. Assistance Orders

4.4. Emotional Competency Profile of Pediatric Hematology Nurses

4.4.1. The Need to Promote the Social-Emotional Development of the Nursing Professional
4.4.2. Nursing Emotional Competency Model
4.4.3. Everything that Can Be Done with an Emotion
4.4.4. Health in Nursing Pediatric Hematology

4.5. Therapeutic Communication in Pediatric Hematology

4.5.1. Specific Skills for Effective and Affective Communication
4.5.2. Key Ideas in Relation to the Child and the Family
4.5.3. Key Ideas in Relation to the Times of Illness
4.5.4. Key Ideas in Relation to Intra- and Interprofessional Practice

4.6. The Influence of the Environment and the Surroundings in the Accompaniment of the Child with Hematologic Pathology

4.6.1. Occupational Health and Work Teams
4.6.2. Space Architecture
4.6.3. Responsible Environment with a Rights Perspective
4.6.4. The Significance of Spaces

4.7. Family System Accompaniment in Pediatric Hematology

4.7.1. Family as a System
4.7.2. Caring for the Caregiver
4.7.3. Accompanying Processes of High Emotional Impact
4.7.4. Parenting Support
4.7.5. Barriers to Care
4.7.6. Coping with Illness
4.7.7. Systemic Support

4.8. Psychomotor and Affective Development of Infants and Preschoolers with Hematologic Pathology

4.8.1. Accompany the Specific Characteristics in the Infant
4.8.2. Accompany the Specific Characteristics of the Preschool Child
4.8.3. Psychomotor and Affective Development during the Illness

4.8.3.1. Psychomotor Development (Physical Health)
4.8.3.2. Language and Emotional Comfort (Mental and Emotional Health)
4.8.3.3. Socialization (Social Health)
4.8.3.4. Meaning of Life

4.8.3.4.1. Love and Contact
4.8.3.4.2. Growing Up Playing

4.9. Emotion, Storytelling and Meaningful Play in School-Age Children with Hematological Pathology

4.9.1. Accompany the Specific Characteristics of the School-Age Child
4.9.2. Personality Development During Illness

4.9.2.1. Coping (Emotional Health)
4.9.2.2. The Importance of Storytelling (Mental Health)
4.9.2.3. Socialization (Social Health)

4.9.3. Meaning of Life

4.9.3.1. Self-Esteem, Self-Image and Self-Concept
4.9.3.2. Pedagogical Support
4.9.3.3. Meaningful Play

4.10. Emotion, Narrative and Socialization in Adolescents with Hematologic Pathology

4.10.1.To Follow the Specific Characteristics of the Adolescent
4.10.2. Personality Development During Illness

4.10.2.1. Coping (Emotional Health)
4.10.2.2. The Importance of Storytelling (Mental Health)
4.10.2.3. Socialization (Social Health)

4.10.3. Meaning of Life

4.10.3.1. Self-Esteem, Self-Image and Self-Concept
4.10.3.2. Pedagogical and Social Support
4.10.3.3. Affective-Sexual Development    

Acquires the indispensable skills to accompany the family system in pediatric hematology”